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Active Ingredients:

• Furosemide

What should you know about the Furosemide therapeutic effects?

Loop diuretic, provokes fast, strong and transient diuresis and possesses hypotensive effect. Increases excretion of K +, Ca2 +, Mg2 +.

When is the drug prescribed?

Edematous syndrome in CHF II-III degree, liver cirrhosis, kidney disease (including in nephrotic syndrome), acute heart failure (pulmonary edema), cerebral edema, hypertensive crisis (either independently or in combination with other antihypertensive drugs), severe hypertension , hypercalcemia, in case of forced diuresis while poisoning with chemical compounds that are excreted unchanged renally; eclampsia.

In which cases you must be cautious or completely discontinue the drug?

• Hypersensitivity
• acute renal failure with anuria (the value of glomerular filtration rate less than 3.5 ml / min)
• severe hepatic failure, hepatic coma and precoma
• urethral stenosis, acute glomerulonephritis, urethremphraxis
• precomatose conditions, hyperglycemic coma
• hyperuricemia
• gout
• decompensated mitral or aortic stenosis
• hypertrophic cardiomyopathy
• increased central venous pressure (above 10 Mmhg), hypotension, acute myocardial infarction
• pancreatitis
• water-electrolyte metabolism dysfunctions
• digital intoxication
• with caution: hyperplasia of prostate gland, lupus, hypoproteinemia, diabetes, stenosing atherosclerosis of cerebral arteries, pregnancy (especially the first half), the period of lactation.

Which undesirable side effects may be caused by the drug?

The Furosemide adverse effects include:

• cardiovascular system: decrease of blood pressure, orthostatic hypotension, collapse, tachycardia, arrhythmias, decreased CBV
• nervous system: dizziness, headache, myasthenia gravis, leg cramps (tetany), paresthesia, apathy, adynamia, weakness, lethargy, drowsiness, confusion
• senses: visual and hearing disorders
• digestive system: loss of appetite, dry mouth, thirst, nausea, vomiting, constipation or diarrhea, cholestatic jaundice, pancreatitis (recrudescence)
• urogenital system: oliguria, acute urinary retention (in patients with prostatic hypertrophy), interstitial nephritis, hematuria, reduced potency
• allergic reactions: purpura, urticaria, exfoliative dermatitis and exudative erythema multiforme, vasculitis, necrotizing vasculitis, itchy skin, chills, fever, photosensitivity, anaphylactic shock
• haemopoietic system: leukopenia, thrombocytopenia, agranulocytosis, aplastic anemia
• water-electrolyte metabolism: hypovolemia, dehydration (the risk of thrombosis and thromboembolism), hypokalemia, hyponatremia, chloropenia, hypocalcemia, hypomagnesemia, metabolic alkalosis
• laboratory values: hyperglycemia, hypercholesterolemia, hyperuricaemia, glycosuria, hypercalciuria

If any of the above apply to you please contact your doctor immediately. Some of the rare occurring side effects may not be included here. For any other risks associated with Furosemide contact your health care provider.

Possible interactions between Furosemide and other drugs, supplements and vitamins:

• antibiotics
• antitumour agents
• hypotensive agents
• bronchodilators
• hypoglycemic agents
• anti-gout drugs
• Li+ drugs
• neuromuscular relaxants
• tubular secretion blockers
• glucocorticoids
• cardiac glycosides
• NSAIDs

Tell your doctor if you are taking any of the above mentioned preparations or any other drugs, food supplements or vitamins as they may alter the effectiveness and increase the possibility of adverse effects occurrence when using Furosemide.

Warning:

• The preparation should not be used for conditions other then stated by the drug manufacturer.
• If the preparation is intended to be used in children consult your health care provider for other unique contradictions and cautions which may apply to the case.

Keep the drug as well as any other disposable material out of the reach of children.