More about Stablon

Stablon reduce the body's brain and hormonal response to stress

How does Stablon affect our body?

Stablon is a unique drug among the class of antidepressants, due to the fact that it works in a completely different way when compared to other antidepressants.

The group of drugs to which Stablon (Tianeptine) belongs to is called serotonin reuptake enhancers. So the preparation unlike other drugs in his class which prevent reuptake of serotonin, exerts the exact opposite effect. The preparation stimulates the reuptake of the neurotransmitter thus decreasing the levels of serotonin in the synaptic gap.

The mechanism of Stablons effect is still unknown, however it can be described as neuroprotective. The drugs therapeutic action presumably can be explained by the adaptation which occurs to the decreased levels of serotonin thus achieving an antidepressant effect.

What are the effects of taking Stablon?

The aim of Stablon is to reduce the body's brain and hormonal response to stress. If we find ourselves under persistent physical and psychosocial stress, our adrenal glands secrete excessive amounts of the corticosteroid hormone cortisol. Excess cortisol is not good for us and can induce changes in the brain's hippocampus. If you are genetically susceptible these changes may not just result in lowering of your mood but can cause clinical depression.

Current evidence suggests that one of the ways in which Stablon achieves a reduced response to stress is by preventing, and possibly even reversing, stress-induced neural damage. Sustained use of Stablon appears to 'normalise' the hypothalamic-pituitary-adrenal (HPA) axis. The HPA axis is a complex set of direct influences and feedback interactions that exist between the hypothalamus, the pituitary gland and the adrenal glands. They represent a major part of the neuro-endocrine system which is responsible for controlling the body's reaction to stress and which regulates many body processes, including energy storage and expenditure, the immune system, digestion, sexuality, moods and emotions. By reducing stress- evoked activity of the HPA, the patient is better able to cope in a stressful environment.

Taking Stablon over a period of time may also help to reduce some stress induced programmed cell death (apoptosis). At a molecular level, Stablon exerts its actions on the glutamate system. Glutamate is the most abundant excitatory neurotransmitter in the human nervous system. It is involved in a number of functions including memory and learning. Stablon appears to prevent the overstimulation of certain types of glutamate receptors in the brain's hippocampus. It also modulates what are known as NMDA glutamate receptors. These particular receptors play a crucial role in mediating both the functional and intracellular effects of stress.

And it is because it has both antidepressant and anxiolytic (anxiety reducing) properties that Stablon is particularly suitable for the treatment of an entire range of depressive conditions.